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Figure 4 | Acta Neuropathologica Communications

Figure 4

From: Peripheral nervous system insulin resistance in ob/ob mice

Figure 4

The PNS of ob/ob mice showed reduced insulin-induced Akt activation in response to intraperitoneally-delivered insulin. Nondiabetic and ob/ob diabetic mice were given intraperitoneal injections of PBS (nondiabetic n = 3, ob/ob n = 3) or insulin at a dose of 3.33 U/kg (nondiabetic n =3 and ob/ob n = 3). In both the DRG (A) and sciatic nerve (B) of nondiabetic mice, there was a significant increase in Akt activation in the insulin stimulated group as compared to mice that received PBS, yet no statistically significant changes were observed in the PNS from ob/ob mice. * = p < 0.05, ** = p < 0.01.

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