Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study

Table 1 Two by two tables comparing the neuropathologists vs radiologists averaged dichotomized scores for periventricular and deep WM lesions, along with the kappa statistics, the Mc Nemar test to compare discordant pair (shown as cells with darker background), sensitivity and specificity values (neuropathology as gold standard)

		Radiologist			Sensitivity			Specificity
		Score < 1.5	Score ≥ 1.5	Total	Estimate	95% CI		Estimate	95% CI
Periventricular demyelination
Pathologist	Score < 1.5	25	28	53	0.83	0.36	1.00	0.47	0.33	0.61
Pathologist	Score ≥ 1.5	1	5	6
	Total	26	33	59
Deep WM demyelination
Pathologist	Score < 1.5	30	4	34	0.44	0.24	0.65	0.88	0.73	0.97
Pathologist	Score ≥ 1.5	14	11	25
	Total	44	15	59

ISSN: 2051-5960