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Table 1 Two by two tables comparing the neuropathologists vs radiologists averaged dichotomized scores for periventricular and deep WM lesions, along with the kappa statistics, the Mc Nemar test to compare discordant pair (shown as cells with darker background), sensitivity and specificity values (neuropathology as gold standard)

From: Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study

   Radiologist Sensitivity Specificity
   Score < 1.5 Score ≥ 1.5 Total Estimate 95% CI Estimate 95% CI
Periventricular demyelination          
 Pathologist Score < 1.5 25 28 53 0.83 0.36 1.00 0.47 0.33 0.61
Score ≥ 1.5 1 5 6       
  Total 26 33 59       
Deep WM demyelination         
 Pathologist Score < 1.5 30 4 34 0.44 0.24 0.65 0.88 0.73 0.97
Score ≥ 1.5 14 11 25       
  Total 44 15 59