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Figure 4 | Acta Neuropathologica Communications

Figure 4

From: Extensive aggregation of α-synuclein and tau in juvenile-onset neuroaxonal dystrophy: an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site

Figure 4

Schema of the distribution of Lewy bodies (LBs), neurofibrillary tangles (NFTs), and iron deposition in the patient. a LBs were diffusely spread in the cerebral cortices and were most abundant in the limbic system, hypothalamus, nucleus basalis of Meynert, substantia nigra (SN), and locus ceruleus. The olfactory bulbs and dorsal motor nucleus of the vagus contained only mild LB pathology. There were no p-α-synuclein-positive structures in the peripheral sympathetic ganglia and dorsal root ganglia. b NFTs were predominantly observed in the limbic system, which corresponded to Alzheimer’s disease in Braak stage IV. c Iron-positive granules were found in the putamen, internal segment of the globus pallidus, caudate nucleus, SN, and periaqueductal gray matter. DRG: dorsal root ganglia, Olf: olfactory bulb, SG: sympathetic ganglia. Semi-quantitative scale for LBs and NFTs: dot-pattern = 1–10, gray = 10–20, black > 20. Number of lesions in a field observed using a 10× objective. Iron-positive granules: dot-pattern = mild, gray = moderate, black = severe.

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