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  1. Research

    Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery

    Recent updating of the World Health Organization (WHO) classification of central nervous system (CNS) tumors in 2016 demonstrates the first organized effort to restructure brain tumor classification by incorpo...

    Patrick J. Cimino, Michael Zager, Lisa McFerrin, Hans-Georg Wirsching, Hamid Bolouri, Bettina Hentschel, Andreas von Deimling, David Jones, Guido Reifenberger, Michael Weller and Eric C. Holland

    Acta Neuropathologica Communications 2017 5:39

    Published on: 22 May 2017

  2. Research

    Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss

    α-Synuclein is a protein involved in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). We investigated the role of ne...

    Jessica Grigoletto, Katharina Pukaß, Ayelet Gamliel, Dana Davidi, Rachel Katz-Brull, Christiane Richter-Landsberg and Ronit Sharon

    Acta Neuropathologica Communications 2017 5:37

    Published on: 8 May 2017

  3. Research

    Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene

    Congenital hydrocephalus is considered as either acquired due to haemorrhage, infection or neoplasia or as of developmental nature and is divided into two subgroups, communicating and obstructive. Congenital h...

    Pascale Saugier-Veber, Florent Marguet, François Lecoquierre, Homa Adle-Biassette, Fabien Guimiot, Sara Cipriani, Sophie Patrier, Marie Brasseur-Daudruy, Alice Goldenberg, Valérie Layet, Yline Capri, Marion Gérard, Thierry Frébourg and Annie Laquerrière

    Acta Neuropathologica Communications 2017 5:36

    Published on: 1 May 2017

  4. Letter to the Editor

    Response to Simon et al.,

    Wei Wei, Michael J. Keogh, James W. Ironside and Patrick F. Chinnery

    Acta Neuropathologica Communications 2017 5:34

    Published on: 29 April 2017

  5. Research

    Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

    Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accum...

    Franc Llorens, Katrin Thüne, Beata Sikorska, Matthias Schmitz, Waqas Tahir, Natalia Fernández-Borges, Maria Cramm, Nadine Gotzmann, Margarita Carmona, Nathalie Streichenberger, Uwe Michel, Saima Zafar, Anna-Lena Schuetz, Ashish Rajput, Olivier Andréoletti, Stefan Bonn…

    Acta Neuropathologica Communications 2017 5:35

    Published on: 27 April 2017

  6. Research

    Enhanced neuroinvasion by smaller, soluble prions

    Infectious prion aggregates can propagate from extraneural sites into the brain with remarkable efficiency, likely transported via peripheral nerves. Yet not all prions spread into the brain, and the physical ...

    Cyrus Bett, Jessica Lawrence, Timothy D. Kurt, Christina Orru, Patricia Aguilar-Calvo, Anthony E. Kincaid, Witold K. Surewicz, Byron Caughey, Chengbiao Wu and Christina J. Sigurdson

    Acta Neuropathologica Communications 2017 5:32

    Published on: 21 April 2017

  7. Research

    Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene

    Frontotemporal Lobar Degeneration (FTLD) encompasses certain related neurodegenerative disorders which alter behaviour, personality and language. Heterogeneous ribonuclear proteins (hnRNPs) maintain RNA metabo...

    Yvonne S. Davidson, Louis Flood, Andrew C. Robinson, Yoshihiro Nihei, Kohji Mori, Sara Rollinson, Anna Richardson, Bridget C. Benson, Matthew Jones, Julie S. Snowden, Stuart Pickering-Brown, Christian Haass, Tammaryn Lashley and David M. A. Mann

    Acta Neuropathologica Communications 2017 5:31

    Published on: 21 April 2017

  8. Research

    Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein

    Studies in vivo and in vitro have suggested that the mechanism underlying Alzheimer’s disease (AD) neuropathogenesis is initiated by an interaction between the cellular prion protein (PrPC) and amyloid-β oligomer...

    Richard Rubenstein, Binggong Chang, Natalia Grinkina, Eleanor Drummond, Peter Davies, Meir Ruditzky, Deep Sharma, Kevin Wang and Thomas Wisniewski

    Acta Neuropathologica Communications 2017 5:30

    Published on: 18 April 2017

  9. Research

    Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

    An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sen...

    Sarah Mizielinska, Charlotte E. Ridler, Rubika Balendra, Annora Thoeng, Nathan S. Woodling, Friedrich A. Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge and Adrian M. Isaacs

    Acta Neuropathologica Communications 2017 5:29

    Published on: 18 April 2017

  10. Research

    Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma

    Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectabl...

    Tina Y. Huang, Andrea Piunti, Rishi R. Lulla, Jin Qi, Craig M. Horbinski, Tadanori Tomita, C. David James, Ali Shilatifard and Amanda M. Saratsis

    Acta Neuropathologica Communications 2017 5:28

    Published on: 17 April 2017

  11. Research

    Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

    Cerebral amyloid angiopathy (CAA) induces various forms of cerebral infarcts and hemorrhages from vascular amyloid-β accumulation, resulting in acceleration of cognitive impairment, which is currently untreata...

    Satoshi Saito, Yumi Yamamoto, Takakuni Maki, Yorito Hattori, Hideki Ito, Katsuhiko Mizuno, Mariko Harada-Shiba, Raj N. Kalaria, Masanori Fukushima, Ryosuke Takahashi and Masafumi Ihara

    Acta Neuropathologica Communications 2017 5:26

    Published on: 4 April 2017

  12. Research

    Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

    Intrathecal immunoglobulin G (IgG) synthesis, cerebrospinal fluid (CSF) oligoclonal IgG bands and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Both the specific ta...

    Yiting Liu, Katherine S. Given, Danielle E. Harlow, Adeline M. Matschulat, Wendy B. Macklin, Jeffrey L. Bennett and Gregory P. Owens

    Acta Neuropathologica Communications 2017 5:25

    Published on: 24 March 2017

  13. Research

    Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis

    Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca2+) homeostasis can exacerbate many of the facto...

    David R. Amici, Iago Pinal-Fernandez, Davi A. G. Mázala, Thomas E. Lloyd, Andrea M. Corse, Lisa Christopher-Stine, Andrew L. Mammen and Eva R. Chin

    Acta Neuropathologica Communications 2017 5:24

    Published on: 22 March 2017

  14. Research

    A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broadly applicable biomarker. Continued focus on mutation-specific upstream mechanisms has yet to pred...

    Johnathan Cooper-Knock, Claire Green, Gabriel Altschuler, Wenbin Wei, Joanna J. Bury, Paul R. Heath, Matthew Wyles, Catherine Gelsthorpe, J. Robin Highley, Alejandro Lorente-Pons, Tim Beck, Kathryn Doyle, Karel Otero, Bryan Traynor, Janine Kirby, Pamela J. Shaw…

    Acta Neuropathologica Communications 2017 5:23

    Published on: 16 March 2017

  15. Research

    Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

    Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease. Here, we investigated whether the G2019S LRRK2 mutation causes morphological and/or function...

    Francesco Longo, Daniela Mercatelli, Salvatore Novello, Ludovico Arcuri, Alberto Brugnoli, Fabrizio Vincenzi, Isabella Russo, Giulia Berti, Omar S. Mabrouk, Robert T. Kennedy, Derya R. Shimshek, Katia Varani, Luigi Bubacco, Elisa Greggio and Michele Morari

    Acta Neuropathologica Communications 2017 5:22

    Published on: 14 March 2017

  16. Research

    Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice

    We previously demonstrated that transplantation of murine neural stem cells (NSCs) can improve motor and cognitive function in a transgenic model of Dementia with Lewy Bodies (DLB). These benefits occurred wit...

    Anita Lakatos, Natalie R. S. Goldberg and Mathew Blurton-Jones

    Acta Neuropathologica Communications 2017 5:21

    Published on: 10 March 2017

  17. Research

    A novel form of necrosis, TRIAD, occurs in human Huntington’s disease

    We previously reported transcriptional repression-induced atypical cell death of neuron (TRIAD), a new type of necrosis that is mainly regulated by Hippo pathway signaling and distinct from necroptosis regulat...

    Emiko Yamanishi, Kazuko Hasegawa, Kyota Fujita, Shizuko Ichinose, Saburo Yagishita, Miho Murata, Kazuhiko Tagawa, Takumi Akashi, Yoshinobu Eishi and Hitoshi Okazawa

    Acta Neuropathologica Communications 2017 5:19

    Published on: 8 March 2017

  18. Research

    Genetic and epigenetic stability of oligodendrogliomas at recurrence

    Among diffuse gliomas, oligodendrogliomas show relatively better prognosis, respond well to radiotherapy and chemotherapy, and seldom progress to very aggressive tumors. To elucidate the genetic and epigenetic...

    Koki Aihara, Akitake Mukasa, Genta Nagae, Masashi Nomura, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno, Junji Shibahara, Miwako Takahashi, Toshimitsu Momose, Shota Tanaka, Shunsaku Takayanagi, Shunsuke Yanagisawa, Takahide Nejo, Satoshi Takahashi, Mayu Omata…

    Acta Neuropathologica Communications 2017 5:18

    Published on: 7 March 2017

  19. Erratum

    Erratum to: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

    Wei Wei, Michael J. Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot, Martin R. Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj…

    Acta Neuropathologica Communications 2017 5:17

    Published on: 22 February 2017

    The original article was published in Acta Neuropathologica Communications 2017 5:13

  20. Methodology article

    Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

    Microglia are key players in the central nervous system in health and disease. Much pioneering research on microglia function has been carried out in vivo with the use of genetic animal models. However, to ful...

    Mark R. Mizee, Suzanne S. M. Miedema, Marlijn van der Poel, Adelia, Karianne G. Schuurman, Miriam E. van Strien, Jeroen Melief, Joost Smolders, Debbie A. Hendrickx, Kirstin M. Heutinck, Jörg Hamann and Inge Huitinga

    Acta Neuropathologica Communications 2017 5:16

    Published on: 17 February 2017

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