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  1. Research

    Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis

    Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca2+) homeostasis can exacerbate many of the facto...

    David R. Amici, Iago Pinal-Fernandez, Davi A. G. Mázala, Thomas E. Lloyd, Andrea M. Corse, Lisa Christopher-Stine, Andrew L. Mammen and Eva R. Chin

    Acta Neuropathologica Communications 2017 5:24

    Published on: 22 March 2017

  2. Research

    A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broadly applicable biomarker. Continued focus on mutation-specific upstream mechanisms has yet to pred...

    Johnathan Cooper-Knock, Claire Green, Gabriel Altschuler, Wenbin Wei, Joanna J. Bury, Paul R. Heath, Matthew Wyles, Catherine Gelsthorpe, J. Robin Highley, Alejandro Lorente-Pons, Tim Beck, Kathryn Doyle, Karel Otero, Bryan Traynor, Janine Kirby, Pamela J. Shaw…

    Acta Neuropathologica Communications 2017 5:23

    Published on: 16 March 2017

  3. Research

    Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

    Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease. Here, we investigated whether the G2019S LRRK2 mutation causes morphological and/or function...

    Francesco Longo, Daniela Mercatelli, Salvatore Novello, Ludovico Arcuri, Alberto Brugnoli, Fabrizio Vincenzi, Isabella Russo, Giulia Berti, Omar S. Mabrouk, Robert T. Kennedy, Derya R. Shimshek, Katia Varani, Luigi Bubacco, Elisa Greggio and Michele Morari

    Acta Neuropathologica Communications 2017 5:22

    Published on: 14 March 2017

  4. Research

    Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice

    We previously demonstrated that transplantation of murine neural stem cells (NSCs) can improve motor and cognitive function in a transgenic model of Dementia with Lewy Bodies (DLB). These benefits occurred wit...

    Anita Lakatos, Natalie R. S. Goldberg and Mathew Blurton-Jones

    Acta Neuropathologica Communications 2017 5:21

    Published on: 10 March 2017

  5. Research

    A novel form of necrosis, TRIAD, occurs in human Huntington’s disease

    We previously reported transcriptional repression-induced atypical cell death of neuron (TRIAD), a new type of necrosis that is mainly regulated by Hippo pathway signaling and distinct from necroptosis regulat...

    Emiko Yamanishi, Kazuko Hasegawa, Kyota Fujita, Shizuko Ichinose, Saburo Yagishita, Miho Murata, Kazuhiko Tagawa, Takumi Akashi, Yoshinobu Eishi and Hitoshi Okazawa

    Acta Neuropathologica Communications 2017 5:19

    Published on: 8 March 2017

  6. Research

    Genetic and epigenetic stability of oligodendrogliomas at recurrence

    Among diffuse gliomas, oligodendrogliomas show relatively better prognosis, respond well to radiotherapy and chemotherapy, and seldom progress to very aggressive tumors. To elucidate the genetic and epigenetic...

    Koki Aihara, Akitake Mukasa, Genta Nagae, Masashi Nomura, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno, Junji Shibahara, Miwako Takahashi, Toshimitsu Momose, Shota Tanaka, Shunsaku Takayanagi, Shunsuke Yanagisawa, Takahide Nejo, Satoshi Takahashi, Mayu Omata…

    Acta Neuropathologica Communications 2017 5:18

    Published on: 7 March 2017

  7. Erratum

    Erratum to: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

    Wei Wei, Michael J. Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot, Martin R. Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj…

    Acta Neuropathologica Communications 2017 5:17

    Published on: 22 February 2017

    The original article was published in Acta Neuropathologica Communications 2017 5:13

  8. Methodology article

    Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

    Microglia are key players in the central nervous system in health and disease. Much pioneering research on microglia function has been carried out in vivo with the use of genetic animal models. However, to ful...

    Mark R. Mizee, Suzanne S. M. Miedema, Marlijn van der Poel, Adelia, Karianne G. Schuurman, Miriam E. van Strien, Jeroen Melief, Joost Smolders, Debbie A. Hendrickx, Kirstin M. Heutinck, Jörg Hamann and Inge Huitinga

    Acta Neuropathologica Communications 2017 5:16

    Published on: 17 February 2017

  9. Research

    High plasticity of axonal pathology in Alzheimer’s disease mouse models

    Axonal dystrophies (AxDs) are swollen and tortuous neuronal processes that are associated with extracellular depositions of amyloid β (Aβ) and have been observed to contribute to synaptic alterations occurring...

    Lidia Blazquez-Llorca, Susana Valero-Freitag, Eva Ferreira Rodrigues, Ángel Merchán-Pérez, J. Rodrigo Rodríguez, Mario M. Dorostkar, Javier DeFelipe and Jochen Herms

    Acta Neuropathologica Communications 2017 5:14

    Published on: 7 February 2017

  10. Research

    Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

    Mitochondria play a key role in common neurodegenerative diseases and contain their own genome: mtDNA. Common inherited polymorphic variants of mtDNA have been associated with several neurodegenerative disease...

    Wei Wei, Michael J. Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot, Martin R. Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj…

    Acta Neuropathologica Communications 2017 5:13

    Published on: 2 February 2017

    The Erratum to this article has been published in Acta Neuropathologica Communications 2017 5:17

  11. Research

    Propagation of pathological α-synuclein in marmoset brain

    α-Synuclein is a defining, key component of Lewy bodies and Lewy neurites in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), as well as glial cytoplasmic inclusions in multiple system atrophy (MS...

    Aki Shimozawa, Maiko Ono, Daisuke Takahara, Airi Tarutani, Sei Imura, Masami Masuda-Suzukake, Makoto Higuchi, Kazuhiko Yanai, Shin-ichi Hisanaga and Masato Hasegawa

    Acta Neuropathologica Communications 2017 5:12

    Published on: 2 February 2017

  12. Methodology article

    AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

    α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD). AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey substantia nigra (SN) induces degenerat...

    Chi Wang Ip, Laura-Christin Klaus, Akua A. Karikari, Naomi P. Visanji, Jonathan M. Brotchie, Anthony E. Lang, Jens Volkmann and James B. Koprich

    Acta Neuropathologica Communications 2017 5:11

    Published on: 1 February 2017

  13. Research

    Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer’s disease

    MicroRNAs (miRNAs) are attractive molecules to utilize as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer’s disease (AD) because miRNAs are relatively stable in biofluid, in...

    Norikazu Hara, Masataka Kikuchi, Akinori Miyashita, Hiroyuki Hatsuta, Yuko Saito, Kensaku Kasuga, Shigeo Murayama, Takeshi Ikeuchi and Ryozo Kuwano

    Acta Neuropathologica Communications 2017 5:10

    Published on: 31 January 2017

  14. Research

    Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency

    Mutations resulting in haploinsufficiency of progranulin (PGRN) cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. Accumulating evidenc...

    Xiaolai Zhou, Lirong Sun, Owen Adam Brady, Kira A. Murphy and Fenghua Hu

    Acta Neuropathologica Communications 2017 5:9

    Published on: 26 January 2017

  15. Research

    Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

    A major feature of Alzheimer’s disease (AD) is the loss of noradrenergic locus coeruleus (LC) projection neurons that mediate attention, memory, and arousal. However, the extent to which the LC projection syst...

    Sarah C. Kelly, Bin He, Sylvia E. Perez, Stephen D. Ginsberg, Elliott J. Mufson and Scott E. Counts

    Acta Neuropathologica Communications 2017 5:8

    Published on: 21 January 2017

  16. Research

    Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

    Neurodegenerative disorders such as Parkinson’s Disease (PD), PD dementia (PDD) and Dementia with Lewy bodies (DLB) are characterized by progressive accumulation of α-synuclein (α-syn) in neurons. Recent studi...

    Brian Spencer, Elvira Valera, Edward Rockenstein, Cassia Overk, Michael Mante, Anthony Adame, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Dora Games, Robert A. Rissman and Eliezer Masliah

    Acta Neuropathologica Communications 2017 5:7

    Published on: 13 January 2017

  17. Research

    Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies

    Microtubule associated protein tau (tau) deposition is associated with a spectrum of neurodegenerative diseases collectively termed tauopathies. We have previously shown that amyotrophic lateral sclerosis (ALS...

    Alexander J. Moszczynski, Wencheng Yang, Robert Hammond, Lee Cyn Ang and Michael J. Strong

    Acta Neuropathologica Communications 2017 5:6

    Published on: 11 January 2017

  18. Research

    Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease

    The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So f...

    Thomas Geuens, Vicky De Winter, Nicholas Rajan, Tilmann Achsel, Ligia Mateiu, Leonardo Almeida-Souza, Bob Asselbergh, Delphine Bouhy, Michaela Auer-Grumbach, Claudia Bagni and Vincent Timmerman

    Acta Neuropathologica Communications 2017 5:5

    Published on: 11 January 2017

  19. Research

    Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity

    Neuropathological and genetic findings suggest that the presynaptic protein α-synuclein (aSyn) is involved in the pathogenesis of synucleinopathy disorders, including Parkinson’s disease (PD), dementia with Le...

    Daniel Ysselstein, Benjamin Dehay, Isabel M. Costantino, George P. McCabe, Matthew P. Frosch, Julia M. George, Erwan Bezard and Jean-Christophe Rochet

    Acta Neuropathologica Communications 2017 5:3

    Published on: 10 January 2017

  20. Research

    Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade

    The role of resident microglial cells in the pathogenesis and progression of glial tumors is still obscure mainly due to a lack of specific markers. Recently P2RY12, a P2 purinergic receptor, was introduced as...

    Changbin Zhu, Johan M. Kros, Marcel van der Weiden, PingPin Zheng, Caroline Cheng and Dana A. M. Mustafa

    Acta Neuropathologica Communications 2017 5:4

    Published on: 10 January 2017

  21. Research

    Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson’s disease

    Phosphorylated alpha-synuclein (p-α-syn) containing Lewy bodies (LBs) and Lewy neurites (LNs) are neuropathological hallmarks of Parkinson’s disease (PD) in the central nervous system (CNS). Since they have be...

    Martina Barrenschee, Dimitri Zorenkov, Martina Böttner, Christina Lange, François Cossais, Amelie Bernadette Scharf, Günther Deuschl, Susanne A. Schneider, Mark Ellrichmann, Annette Fritscher-Ravens and Thilo Wedel

    Acta Neuropathologica Communications 2017 5:1

    Published on: 5 January 2017

  22. Research

    Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy

    Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progr...

    Elvira Valera, Brian Spencer, Jerel A. Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats and Eliezer Masliah

    Acta Neuropathologica Communications 2017 5:2

    Published on: 5 January 2017

  23. Research

    β-Amyloid triggers aberrant over-scaling of homeostatic synaptic plasticity

    The over-production of β-amyloid (Aβ) has been strongly correlated to neuronal dysfunction and altered synaptic plasticity in Alzheimer’s disease (AD). Accordingly, it has been proposed that disrupted synaptic...

    James Gilbert, Shu Shu, Xin Yang, Youming Lu, Ling-Qiang Zhu and Heng-Ye Man

    Acta Neuropathologica Communications 2016 4:131

    Published on: 13 December 2016

    The Erratum to this article has been published in Acta Neuropathologica Communications 2017 5:20

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