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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion

Fig. 2

Histological, immunohistochemical and genetic/epigenetic features of the tumor. (a) Histological exam revealed a hypercellular neuroepithelial tumor with ependymoma-like histological pattern including perivascular pseudorosettes, focal calcifications (a, b), and a high proliferation activity (e) with frequent mitotic figures (b, f). Olig2 was expressed in tumor cells and BCOR was negative (c, d). NF staining confirmed a diffuse growth pattern (g). GFAP was negative (h). (j) RNA-based next generation sequencing revealed a BCOR::CREBBP fusion with breakpoints in intron 6 of BCOR and exon 31 of CREBBP. (i) The copy number profile showed focal alterations on chromosomal regions 16p13.3 and Xp11.4 representing the CREBBP and BCOR gene locations

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Acta Neuropathologica Communications

ISSN: 2051-5960

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