Fig. 6
From: LINC complex alterations are a key feature of sporadic and familial ALS/FTD
SUN1 is mislocalized in the cytoplasm in cortical neurons of sporadic and C9-ALS patients. Representative images of motor cortex sections from control (a, b), sALS (d, e) and C9-ALS (g, h) patients stained with antibodies specific for SUN1 (red) and MAP2 (grays). DAPI (blue) was used to label nuclei. White boxes in a, d, and g identify neurons enlarged in b, e, and h. Line profile plots show the marked difference of SUN1 distribution in sALS (f) and C9-ALS (i) cortical neurons compared to controls (c). The yellow dashed lines in a indicate the lines used for the profile plots. Scale bars: 20 μm in main panels, 10 μm in zoomed-in images