Fig. 1

Comparison of response to IOP elevation with RGC soma counts and dendritic arbourisations in a mouse glaucoma model. A IOP elevation was induced using intracameral injection of polyurethane microbeads in mouse eyes (26 retinas from 13 mice). B IOP curves of four groups which were divided by the IOP of 17 mmHg at week 1. C The Cumulative IOP graph shows that the IOP elevation was statistically significant in both the RBPMS high group and the DiOlistics high group compared to the RBPMS low group and the DiOlistics low group, respectively. D In the RBPMS low OHT group, the count of RBPMS+ RGCs was similar to the control group. However, the count of RBPMS+ RGCs was lower, with marginal significance in the RBPMS high OHT group compared to the control group. Each value of the box plot is an average of the RGC counts in one retina. Scale bar = 20 μm. E Whereas the statistically significant change of dendritic arbour was apparent in both the DiOlistics low group as well as the DiOlistics high group compared to the control group. Scale bar = 50 μm. NT normal tension (control group), OHT ocular hypertension (treated group). ^ap = 0.05, *p < 0.05, all comparison was performed between each treated group and NT