Fig. 3

Chromosomal microarray analysis results on the tumor samples. (A) Whole-genome view from Case 1, from left to right, displaying chromosomes 1–22, followed by X and Y. Red arrows indicate copy number losses involving 1p, 6p, 9p, 19q, and 22q. (B) Chromosome 7q exhibited an interstitial deletion in the long arm. The breakpoints do not involve the CLIP2 or MET genes, suggesting that the CLIP2::MET fusion likely results from rearrangements in a primarily balanced form. Note that the breakpoints in 1p and 19q were more distal than the typical 1p/19q co-deletions observed in oligodendrogliomas. (C) Whole-genome view from Case 2. Red arrows indicate gain of 1q, several copy number alterations in chromosome 7q, and a loss of chromosome 22. (D) Chromosome 7q showed several copy number alterations, including two interstitial deletions, an interstitial gain, and a terminal loss. Notably, the proximal breakpoint of the 7q11.23q21.11 deletion is within the CLIP2 gene, indicating a potential rearrangement. The MET gene is not included in the copy number alterations observed in 7q.