Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors

Table 1 Correlation of the expression of Nrf2 with clinicopathological features of 32 PitNET patients

	Feature	n	Mean relative Nrf2 expression	p value
Age (years)	< 45	13 (40.625%)	2.15	0.464
	≥ 45	19 (59.375%)	2.26	0.464
Sex	Female	21 (65.625%)	2.21	0.453
	Male	11 (34.375%)	2.07	0.453
Tumor diameter	≤ 1 cm	5 (15.625%)	1.64	0.043*
	> 1 cm and ≤ 3 cm	19 (59.375%)	2.04
	> 3 cm	8 (25%)	2.93
Knosp grade	0	9 (28.125%)	1.26	0.048*
	1	5 (15.625%)	1.34
	2	7 (21.875%)	2.03
	3	4 (12.50%)	2.76
	4	7 (21.875%)	3.34
Recurrence	Yes	6 (18.75%)	3.14	0.041*
	No	26 (81.25%)	1.97	0.041*

* indicates p < 0.05, which is considered a statistically significant difference

ISSN: 2051-5960