Fig. 5

The role of Nrf2 in the pathopoiesis of PitNETs. A The inhibitory responses of proliferation for different Nrf2 expressions in MMQ and GH3 cells. n = 3; *p < 0.05, **p < 0.01, ^##p < 0.01. B The inhibitory responses of PRL and GH hormone secretions for different Nrf2 expressions in MMQ and GH3 cells. n = 3; *p < 0.05, **p < 0.01, ^#p < 0.05, ^##p < 0.01. C Colony formation in MMQ and GH3 cell lines. n = 3; *p < 0.05, **p < 0.01. D Left: Representative images of xenograft tumors from mice with different treatment. Right: Tumor volume growth curves and tumor weights of nude mice in different treatment groups. n = 5; *p < 0.05, **p < 0.01, ^#p < 0.05, ^##p < 0.01