Fig. 2
From: Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
Panobinostat demonstrated therapeutic efficacy in PitNETs. A Upper: Representative images of xenograft tumors from mice treated with control vehicle or Panobinostat. Down: Tumor volume growth curves and tumor weights in different treatment groups. n = 6; *p < 0.05, **p < 0.01. B Representative images of TUNEL staining from xenograft tumors. C The inhibitory responses of 18 primary PitNET cell proliferation by Panobinostat. D The cell survival of MMQ and GH3 cells after Panobinostat treatment at different dosage and time points. E The levels of PRL and GH secretions after Panobinostat treatment at different dosage at 24 h. n = 3; *p < 0.05, **p < 0.01. F Representation of colony formations in MMQ and GH3 cell lines. G Representation of Anneix staining in MMQ and GH3 cell lines