Fig. 1

Identification of drug candidates through high-throughput drug screening in PitNETs. A Heat-map representation of drug activities for multiple PitNET cells screened through the HTS library. The gradual shift of color from green to red indicates the primary cell survival percentage from small to large. B Mechanistic drug classes enriched among the 16 ‘hits’ selected based on consistent potency across multiple PitNET primary cell cultures. C Left: An overview of growth inhibition of 3 pituitary adenoma cell lines by compounds targeting various MoAs. Right: A Venn diagram of the left results. D The cell survival of MMQ and GH3 cells for selected agents from the key enriched mechanistic classes HDACs