Fig. 2

P2RY12 positive homeostatic microglia presented a unique quantification pattern in OCC. a Panel of homeostatic microglia which were detected using a P2RY12 antibody. P2RY12 positive microglia showed a highly ramified morphology in all regions. Quantification of P2RY12 positive cells in hippocampus (b), frontal cortex (c), occipital cortex (d) and substantia nigra (e). HPC data points contain hippocampal subregions (CA4-1, subiculum, entorhinal cortex, see Additional file 4: Fig. S3), OCC contains data points from subregions (striate cortex and peristriate cortex). Red – female, blue – male. No sex differences could be shown across the examined brain regions. One-way ANOVA with Tukey's multiple comparisons test was used for statistical analysis. *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar = 60 μm