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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension​

Fig. 3

Validation of the silicone oil model. (A) IOPs were increased after silicone oil (SO) injection (n = 20). (B) Representative confocal images of flat-mounted retina sections showing surviving RBPMS-positive (red) RGCs at 8 weeks. Scale bar = 50 μm. (C) Bar graph indicates % of peripheral RGC loss. (D) Average ERG waveforms of RGC responses (pSTR, -2.5 log cd.s.m− 2) at 8 weeks for each group. (E) Representative OCT images of mouse retina at 8 weeks. GCC: ganglion cell complex, including RNFL, GCL, and IPL layers, indicated by double-ended yellow arrows. (F) Bar graph indicating the % reduction in GCC thickness at 8 weeks. (n = 4–6). ****p < 0.001. (Ctrl- Control; OHT- ocular hypertension)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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