Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairs

Table 1 Melanoma metastasis patient and sample overview

Patient	Intracranial metastasis	Extracranial metastasis	Data origin
P03	1 brain sample	1 lung sample	Westphal et al. [21]
P04	1 brain sample	2 skin samples	Westphal et al. [21]
P08	1 brain sample	3 soft tissue samples	Westphal et al. [21]
P13	1 brain sample	1 lymph node sample	Newly sequenced
P16	1 brain sample	1 lung sample	Westphal et al. [21]
P18	1 brain sample	2 lung samples	Westphal et al. [21]
P39	1 brain sample	1 lung sample	Westphal et al. [21]
P42	1 brain sample	2 lymph node samples	Westphal et al. [21]
P74	1 brain sample	1 lymph node sample	Newly sequenced
P77	1 brain sample	1 lymph node sample	Newly sequenced
P78	1 brain sample	1 small intestine sample	Newly sequenced
P101	1 brain sample	1 liver sample	Newly sequenced
P106	1 brain sample	1 lymph node sample	Newly sequenced
P107	1 brain sample	1 lung sample	Newly sequenced
P108	1 brain sample	1 lymph node sample	Newly sequenced
P111	1 brain sample	1 lymph node sample	Newly sequenced

Each melanoma patient developed an intra- and an extracranial metastasis in the course of its disease. Extracranial metastases developed either in lung, lymph node, skin, liver, small intestine or soft tissue. Multiple samples of the same metastasis were taken if the metastasis contained histologically different regions. The corresponding metastasis transcriptomes of 7 of 16 patients were taken from our previous study by Westphal et al. [21] and the metastasis transcriptomes of 9 of 16 patients were newly sequenced. Additional information about the age of the patients at the resection of the brain metastasis, sex, therapies, and mutational states of BRAF and NRAS are provided in Additional file 18: Table S13

ISSN: 2051-5960