Table 1 Summary of clinical characteristics and clinical course of three cases
| Â | Case 1 | Case 2 | Case 3 |
|---|---|---|---|
Sex | Female | Male | Male |
Age | 43 | 45 | 32 |
Past medical history | Pituitary adenoma (36y) | Mandibular osteosarcoma (26y) | None |
| Â | Left adrenal adenoma (36y) | Gastric cancer (42y) | Â |
| Â | Bilateral breast cancer (40y) | Colon cancer (44y) | Â |
Family history | Mother; breast cancer (38y) | Grand father; gastric cancer (70y) | Mother; bilateral breast cancer (32y) Brother; brain tumor (17y) |
| Â | Daughter; osteosarcoma (18y) | Grand mother; gastric cancer (50y) | Â |
| Â | Son; medulloblastoma (10y) | Aunt; pancreatic cancer (68y) | Â |
Symptom | Left hemiparesis | Gait disturbance | Left hemiparesis |
| Â | Dysarthria | Â | Left sensory disturbance |
Tumor location | Left cerebellar peduncle | Right parietal lobe | Right pons |
| Â | Â | Â | Right parietal lobe |
Surgery | Biopsy | Subtotal resection | Partial resection |
Adjuvant therapy | TMZ, BEV | TMZ | TMZ, TTF |
| Â | Focal irradiation (60Â Gy/30fr) | Focal irradiation (60Â Gy/30fr) | Focal irradiation (60Â Gy/30fr) |
Salvage therapy | Best supportive care | Gross total removal | BEV |
| Â | Â | TMZ, BEV, TTF | Focal irradiation (20Â Gy/5Fr) |
PFS (months) | 17.0 | 5.1 | 9.2 |
OS (months) | 21.7 | 18.6 | 15.3 |