Fig. 4

Status of TP53 gene and chromosome 17 in the three cases. A Summary of TP53 mutation patterns (germline and tumor), VAF (variant allele frequency) and copy numbers of TP53 in Case 1 (left), Case 2 (middle), and Case 3 (right). B–D Dot plots indicating B allele frequency (BAF) of common SNPs on chromosome 17p and 17q in Case 1 (B), Case 2 (C), and Case 3 (D). Higher and lower mismatch ratios of the SNPs are shown as yellow and blue dots, respectively. A red line indicates TP53 gene. All figures were obtained using WES data