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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling

Fig. 8

ADSC-EVs suppress OHT-induced TLR4/MAPK/NF-κB proinflammatory cascade signaling in the OHT mice 2 weeks after injection. (A) Western blot images of TLR4, p-p38 MAPK, p-NFκB, p65, p-ERK, IL-6, TNF-α, and IL-1β relative protein expressions normalized to β-actin levels in the retina (n = 3, *p < 0.05, **p < 0.01, ***p < 0.001). (B) Western blot images of TLR4, p-p38 MAPK, p-NFκB, p65, p-ERK, IL-6, TNF-α, and IL-1β relative protein expressions normalized to β-actin levels in the optic nerve (n = 3, *p < 0.05, **p < 0.01)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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