Experimental animal; age at inoculation | Time of termination | Pathological tau (mass; volume) | Application; injection region (coordinates from bregma) | Speed of application | Pathology | Propagation | References |
---|---|---|---|---|---|---|---|
C57BL/6; 2–3 m | 3,6,9, 18, & 24 m PI | Heparin-treated 2N4R tau PFFs (9 µg; 5 µl) | Unilateral; Hippocampus (A/P = -2.54 mm, L =  + 2 mm, D/V = -2.4 mm) Overlaying primary visual cortex (A/P = -2.54 mm, L =  + 2 mm, D/V = -1.4 mm) | NA | No pathology | Not applicable | [67] |
Self-aggregated 2N4R tau PFFs (9 µg; 5 µl) | Inclusions | Ipsilateral entorhinal cortex, mammillary area, & contralateral hippocampus | |||||
PS19 (1N4R; P301S; C57BL/6); 2–3 m | 1, 3, 6 m PI | Heparin-treated Myc tagged K18 (4R)/P301L tau PFFs (5 µg; 5 µl) | Unilateral; Hippocampus (A/P = -2.5 mm, L =  + 2 mm, D/V = -1.8 mm) Unilateral; Striatum (A/P =  + 0.2 mm, L =  + 2 mm, D/V = -2.6 mm) Overlaying primary visual cortex (A/P =  + 0.2 mm, L =  + 2 mm, D/V = − 0.8 mm) | NA | Inclusions | Substantia nigra, thalamus, locus coeruleus, dorsal raphe nuclei, & neocortex | [75] |
Heparin-treated Myc tagged 4R2N/P301S tau PFFs (10 µg; 5 µl) | CA2, dentate gyrus, entorhinal cortex, locus coeruleus, substantia nigra, striatum, thalamus, & corpus callosum | ||||||
P301L (2N4R; P301L-tau; C57BL/6); 3 m | 2, 7, 14 d 1,2 & 3 m PI | Heparin-treated Myc K18 (4R)/P301L tau PFFs (0.05–25 μg; 2–5 µl) | Unilateral; Hippocampus (A/P = -2.5 mm, L =  + 2 mm, D/V = − 2.4 mm) | 1 µl/min | NFT-like; Th-S positive structures & argyrophilic inclusions | CA3, dentate gyrus, piriform cortex, & hippocampus | [123] |
Unilateral; Frontal cortex area 3; (A/P = + 2 mm, L = + 2 mm, D/V = − 2.7 mm) | Amygdala, thalamus, midbrain, & brainstem | ||||||
T40PL-GFP (2N4R; GFP tagged P301L; B6C3H/J); 2–3 m | 3 m PI | Heparin-treated Alexa Fluor 594-tagged 2N4R/P301L tau PFFs (2 μg; 2.5 μl) | Unilateral; Hippocampus (A/P = -2.5 mm, L = + 2 mm, D/V = 2.4 mm) | NA | NFT-like | Ipsi- & contralateral CA3, dentate gyrus, subiculum, & retrosplenial granular cortex | [58] |
rtg4510 (2N4R P301L; C57BL/6 X FVB); 28 d | 1 m & 2.5 PI | Heparin-treated hTau (2N4R) short filaments (SFs) (5 μg; 2.5 μl) | Unilateral; Cerebral motor cortex 1 (A/P =  − 2.5 mm, M/L = 2 mm, D/V = 1 mm) | 0.5 μl/min | Inclusions | No propagation | [164] |
PS19 (1N4R; P301S; C57BL/6); 2.5 m | 5 m PI | Heparin-treated K18 (4R) tau PFFs (3 µg; 3 µl) | Unilateral; Hippocampus (A/P = − 2.2, L =  − 1.6, D/V =  − 1.2) | 0.3 µl/ min | NT-like | Ipsi- & contralateral hippocampus & cerebral cortex | [162] |
PS19 (1N4R; P301S; C57BL/6); 3 m | 1 & 3 m PI | Heparin-treated His tagged K18 (4R) tau PFFs (5 μg; 5 μl) | Unilateral; Hippocampus (AP = − 2.5 mm, L = − 2.0 mm, DV = − 1.8 mm) | 0.2 μl/min | Inclusions | Ipsi- & contralateral hippocampus, ipsilateral dentate gyrus, entorhinal cortex, retrosplenial cortex | [173] |
Heparin-treated IAPP-K18 (4R) tau PFFs (5 μg; 5 μl) | |||||||
P301L (2N4R, P301L; C57BL/6); 4 m | 6 w PI | Heparin-treated His-tagged K18 (4R)/P301L tau PFFs (5 µg; 1 µl) | Unilateral; Hippocampus (A/P = -1.8 mm, L = -1.72 mm, D/V = -1.8 mm) | 0.2 µl/min | NFT-like | Ipsi- & contralateral hippocampus | [4] |
PS19 (1N4R; P301S; C57BL/6); 2–3 m | 14 d, 1,3, 6 & 12 m PI | Heparin-treated Myc tagged 2N4R/P301S tau PFFs (4 µg; 1 µl) | Unilateral; Locus Coeruleus (A/P = − 5.45 mm, L = + 1.28 mm, D/V = − 3.65 mm) | 0.1 µl/min | NFT- & NT-like | Ipsilateral locus coeruleus, nucleus prepositus hypoglossi, nucleus paragigantocellularis, hypothalamus, amygdala, bed nucleus of the stria terminali, frontal cortex, & spinal cord | [76] |
PS19 (1N4R; P301S; C57BL/6); 3 m | 1.5, 3.5, 6 and 12 m PI | Heparin-treated K18(4R)/P301L tau PFFs (333 μM; 5 µl | Unilateral; Hippocampus (A/P = -2.0 mm, L =  + 1.4 mm, D/V = -1.2 mm) Overlying frontal Cortex (A/P =  + 2.0 mm, L =  + 1.4 mm, D/V = − 1.0 mm) | 1 µl/min | NFT-like | Ipsi- & contralateral hippocampus & frontal cortex | [144] |
Entorhinal cortex (A/P = − 4.8 mm, L = − 3.0 mm, D/V = − 3.7 mm) | Subiculum, hippocampal formation, amygdala, thalamus & frontal cortex | ||||||
Substantia Negra (A/P = − 4.8 mm, angle 16, L = − 1.1 mm, D/V = − 4.7 mm) | Striatum, thalamus, brain stem & cortical regions including the motor cortex | ||||||
PS19 (1N4R; P301S; C57BL/6); 4 m | 3 m PI | Heparin-treated K18(4R)/P301L tau PFFs (66.7 µM; NA) | Unilateral; Hippocampus (A/P = − 2.0 mm, L = + 1.4 mm, D/V = − 1.4 mm) Overlying frontal cortex (A/P = + 2.0 mm, L = + 1.4 mm, D/V = − 1.0 mm) | 1 µl/min | NFT-like | Ipsi- & contralateral hippocampus & frontal cortex | [155] |
Aβ-induced K18(4R)/P301L tau PFFs (66.7 µM; NA) |