Fig. 5

Pick body packing density in hippocampus versus neocortex. A and B show density of tau pathology staining using immunohistochemistry with AT8 antibody in relation to neuronal density. A illustrates the high degree of pathology in the dentate gyrus (DG) of the hippocampus, which also holds a high density of neurons, in Case 13, a 75-year-old male with a 9-year history of PPA. B shows relative density of tau pathology in the left middle frontal gyrus (MFG), a neocortical region with relatively abundant Pick disease pathology, in Case 18, a 71-year-old female with a 14-year history of PPA. Photographs were taken at the same magnification. Inclusion-to-neuron analyses in a subset of cases show that despite differences in neuronal packing density, hippocampal cells, particularly granule cells in the DG, contain significantly more inclusions per neuron (p < 0.05). Bar indicates 100 µm