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Table 1 Demographic details of all the cases and controls

From: Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion

Variable

 

Ageing Controls

PSND

PSD

VaD

Mixed

AD

N

 

13

22

13

16

13

13

Mean Age, years (range)

 

80.1 (72–91)

83.5 (78–94)

87.3 (80–98)

86.9 (76–97)

85.9 (72–94)

83.3 (70–91)

Gender

(M:F%)

 

35:65

57:43

30:70

41:59

44:56

56:44

MMSE,

mean ± SEM

 

29 ± 1

27 ± 0.4

16 ± 1

13 ± 4

11 ± 2

7 ± 2

CAMCOG,

mean ± SEM

 

na

90 ± 1

66 ± 3

na

na

39 ± 7

APOE ε2; ε4 allele frequencies (%)

 

16.7; 16.7

10.0; 25.0

13.3; 13.3

10.0; 0.0

0.0; 30.0

3.6; 39.3

CERAD,

mean (range)

 

0.5

(0–2)

1.7

(1–2)

1.3

(1–3)

1.0

(0–2)

2.9

(2–3) ‡

2.9

(2–3) ‡

ABC

Scores, mean

 

A0.5,

B1.2, C0.5

A0.5,

B1.2, C0.7

A0.5,

B1.2, C0.8

A0.6,

B1.2, C0.8

A2.5,

B2.6, C2.6

A3,

B3, C3

Braak Stage, mean

(range)

 

1.9

(0–4)

2.6

(1–4)

2.6

(1–4)

2.0

(0–4)

5.2

(5–6) ‡

5.6

(5–6) ‡

CAA- frequency (moderate- severe), %

 

6

15

18

17

9

39

Vascular pathology score, mean

(range)†

 

6.7

(0–10) †

13.5

(13–14)

13.3

(9–17)

13.2

(10–16)

11.0

(6–14)

10.8

(3–16)

WML

score, mean (range)

 

0.5

(0–2) †

2.5

(2–3)

2.4

(2–3)

2.9

(2–3)

2.9

(2–3)

1.8

(0–3)

White matter (WM) / Vascular lesions, moderate - severe (%)

 

18.0**

100

100

100

95

72

  1. Numbers represent mean values (± SEM) and where given with the range of values in parentheses. The causes of death included bronchopneumonia (95%), cardiac arrest and carcinoma, renal failure and gastrointestinal bleed with no particular distribution pattern in any group. The post-mortem interval between death and tissue retrieval ranged 24–47 h for all the cases. There were no differences in the length of post-mortem delay between groups. Braak staging scores and Alzheimer’s Disease Neuropathologic changes [36] were different in mixed and AD cases compared to all other groups (‡P < 0.05). Mean vascular pathology scores (range) for PSND and PSD groups were 13.5 (13–14) and 13.3 (9–17) compared to 6.7 (0–10) for controls (†P < 0.05). These scores were derived as described previously, with white matter lesion (WML) pathology score assessed using the scale from Deramecourt et al. [9].. Mean WML Score was high in all post-stroke and dementia subjects compared to controls (†P < 0.01). WM/Vascular lesions had **P < 0.01 compared to all post-stroke and dementia subjects. Abbreviations: ABC: AD Neuropathology scoring system; AD: Alzheimer’s disease; APOE: apolipoprotein E; CAA: cerebral amyloid angiopathy; CAMCOG: Cambridge cognition examination; F: female; M: male; MMSE: Mini Mental state examination; N: number of subjects; na: not available; NPD: no pathological diagnosis; PSND: post-stroke non-demented; PSD: post-stroke dementia; VaD: vascular dementia; WM: white matter
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Acta Neuropathologica Communications

ISSN: 2051-5960

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