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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion

Fig. 4

Assessment of capillary density, hippocampal volume and pericytes number in the hippocampus of BCAS mice. A-C, Representative images showing pericytes in the mouse hippocampus (arrows) subjected to bilateral common carotid artery stenosis (BCAS) using collagen IV (COL4) immunostaining. Scale bar = 50 μm (A); 25 μm (B-C). D, Box plots showing mean volume of the hippocampus in each subfield. BCAS caused CA1 atrophy (P = 0.018). E, Box plots showing number of pericytes per unit capillary length (/mm) in the hippocampus. Pericytes loss was evident in CA1 subfield of the hippocampus after BCAS (P = 0.000). F, Graph showing correlation between number of pericytes per unit capillary length (/mm) in CA1 and CA1 volume of the hippocampus after BCAS. Pericytes number per unit capillary length was positively correlated with CA1 volume (Pearson’s r = 0.54, P = 0.006)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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