Fig. 10
From: Interplay between androgen and CXCR4 chemokine signaling in myelin repair
Schematic illustration of potential role of astrocytic CXCR4 and AR in the remyelinating effect of testosterone. After focal demyelination produced in the ventral mouse spinal cord by the infusion of lysolecithin, the testosterone-dependent remyelination of axons by oligodendrocytes was accompanied by an increase in astrocytes expressing CXCR4 and the androgen receptor within the demyelinated area. Conditional ablation of CXCR4 or AR in astrocytes blocked remyelination by oligodendrocytes