Discovery cohort (n = 310) | Validation cohort (n = 213) | |||||
---|---|---|---|---|---|---|
HC | AD | NAD | HC | AD | NAD | |
Number of cases | 85 | 132 | 93 | 70 | 99 | 44 |
Gender | ||||||
Female | 54 (63.5%) | 68 (51.5%) | 34 (36.6%) | 30 (42.9%) | 70 (70.7%) | 16 (36.4%) |
Male | 31 (36.5%) | 64 (48.5%) | 59 (63.4%) | 40 (57.1%) | 29 (29.3%) | 28 (63.6%) |
Age (years) | ||||||
Mean ± SD | 64.69 ± 13.14 | 66.72 ± 9.064 | 64.20 ± 9.125 | 53.59 ± 15.55 | 63.76 ± 10.81 | 61.66 ± 9.183 |
Range | 45–85 | 46–86 | 43–84 | 37–80 | 47–84 | 49–85 |
MMSE | ||||||
Mean ± SD | 28.81 ± 1.569 | 13.33 ± 7.578 | 24.26 ± 6.035 | 28.04 ± 1.706 | 14.70 ± 6.805 | 17.95 ± 8.618 |
Range | 22–30 | 0–30 | 3–29 | 25–30 | 0–28 | 0–28 |
– | – | – | MoCA | – | – | |
Mean ± SD | – | – | – | 25 ± 2.070 | 8.391 ± 5.698 | 12.23 ± 7.549 |
Range | – | _ | – | 22–28 | 0–25 | 0–26 |
CSF t-tau protein (pg mL−1) (Lumipulse) | Duration of disease (years) | |||||
Mean ± SD | 236.8 ± 73.54 | 468.0 ± 240.9 | 213.0 ± 66.61 | – | 2.605 ± 2.561 | 2.893 ± 1.745 |
Range | 107.0–329.0 | 191.0–1372 | 107.0–420.0 | – | 0.5–12 | 0.5–6 |
CSF p-tau181 protein (pg mL−1) (Lumipulse) | PIB-PET (Centiloid) | |||||
Mean ± SD | 31.13 ± 11.88 | 75.97 ± 44.48 | 26.70 ± 11.30 | 1.607 ± 9.060 | 71.30 ± 22.52 | − 0.4790 ± 10.26 |
Range | 14.00–51.00 | 14.00–203.0 | 11.00–72.00 | − 6.179–17.01 | 13.02–132.3 | − 32.46–17.15 |
CSF t-tau/Aβ42 (Lumipulse) | CSF t-tau protein (pg mL−1) | |||||
Mean ± SD | 0.9503 ± 0.5496 | 3.416 ± 2.528 | 1.079 ± 0.7243 | 153.0 ± 62.51 | 685.8 ± 747.7 | 319.9 ± 103.8 |
Range | 0.3920–2.150 | 0.3477–14.47 | 0.4694–4.292 | 78.76–308.4 | 199.9–2343 | 215.1–422.4 |
CSF p-tau181/Aβ42 (Lumipulse) | CSF Aβ40 protein (pg mL−1) | |||||
Mean ± SD | 0.1146 ± 0.09567 | 0.5698 ± 0.4433 | 0.1203 ± 0.07630 | 17,169 ± 4689 | 11,664 ± 8710 | 13,603 ± 7347 |
Range | 0.04612–0.3643 | 0.05263–2.528 | 0.05943–0.5926 | 12,130–29,803 | 738.8–26,699 | 5947–20,596 |
CSF Aβ40/Aβ42 (Lumipulse) | CSF Aβ42 protein (pg mL−1) | |||||
Mean ± SD | 0.1080 ± 0.04268 | 0.06773 ± 0.02852 | 0.1212 ± 0.02876 | 1757 ± 570 | 442.4 ± 213.7 | 1118 ± 585.6 |
Range | 0.03571–0.1810 | 0.02548–0.1673 | 0.04390–0.1772 | 1128–3196 | 213.6–860.8 | 444.1–1506 |