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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Blood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer’s disease diagnosis and differential diagnosis

Fig. 4

Performance of CNS-derived EVs markers in the discovery cohort a, e the ratio of GABRD+ or GPR162+ EVs in each group. b, f The ratio of pTau217+ EVs in each group. c, g The ratio of GABRD+ or GPR162+- carrying pTau217 EVs in each group. d, h The corresponding size of distribution mode of GABRD+ or GPR162+-carrying pTau217 EVs in each group. i Integrative model combining age, the ratio of GABRD+ or GPR162+-carrying pTau217 EVs, the corresponding size of distribution mode of GABRD+ or GPR162+-carrying pTau217 EVs, distinguished AD from HC. j Integrative model distinguished AD from NAD. *p < 0.05, ***p < 0.001, ****p < 0.0001, one-tailed nonparametric ANOVA followed by Kruskal–Wallis test

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Acta Neuropathologica Communications

ISSN: 2051-5960

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