Fig. 5From: Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosisSchematic representation of the distribution of pathogenic driver mutations and clonal lineage in this patient. Distribution and MAF of three pathogenic somatic mutations (a). Additional NRAS mutation, playing a role as a second driver, accelerated abdominal tumor growth in this patient. Schematic representation of initiation and progression of tumor in the present case (b). Abbreviations: DUP: Duplication; LOH: Loss-of-heterozygosity; MAF: mutant allele frequencyBack to article page