Fig. 2
From: Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis
Sharing of somatic mutation profiles defined by multiregional whole exome sequencing. Sharing pattern and types of somatic mutations among six tissues (a). Three somatic mutations, GNAQ, S1PR3, and NRAS, were determined to be pathogenic. GNAQ and NRAS (listed in red) have been reported to be associated with tumorigenesis in melanocytic tumors. On the other hand, S1PR3 (listed in orange) has been reported to be associated with cancer in other sites but not reported in melanocytic tumors. Distribution of MAF of somatic mutations shared among brain and abdominal tumors (b). GNAQ and S1PR3 were shared among brain and abdominal tumors, while NRAS was detected only in the abdominal tumors. Abbreviations: MAF: mutant allele frequency