Fig. 7
From: The genomic alterations in glioblastoma influence the levels of CSF metabolites
Levels of metabolites measured by MRS (Lactate, γ-aminobutyric acid (GABA), and choline) are influenced by tumor mutations. CSF samples from GBM TP53-wildtype patients show significantly elevated levels of (A) lactate, (B) GABA, and (C) choline. CSF samples from GBM PTEN-mutant patients show elevated levels of (D) GABA, (E) lactate, and (F) choline. Each colored dot represents a patient, small black dot indicates samples that are 1.5 times the interquartile range above the upper quartile or below the lower quartile