Fig. 4
From: The genomic alterations in glioblastoma influence the levels of CSF metabolites
CSF metabolite levels differ with TP53 mutation status. (A) Supervised heat map of metabolites (n = 125) with CSF samples grouped based on TP53 status (mutant vs. wildtype). (B) Volcano plot of metabolites comparing GBM-TP53-mutant vs. GBM-TP53-wildtype. Colored points represent metabolites that are present at significantly different levels (-log10(p-value) > 1.3, log2(Mut/WT) > + 1.5 or < -1.5) between GBM-TP53-wildtype and GBM-TP53-mutant samples. Five carnitine compounds, choline, and γ-aminobutyric acid (GABA) are highly abundant in CSF from TP53-wildtype patients. (C) sPLS-DA plot of CSF metabolites status shows clear separation between TP53-mutant vs. TP53-wildtype samples