Fig. 10

Schematic showing the preliminary mechanism of Gnao1 in SCs regulating SC differentiation and myelination. Gnao1 deficiency triggering spontaneous differentiation of SCs through the following two ways: (1) The absence of Gnao1 in SCs reduced the content of the Gαo, resulting in the depolymerization of Gαβγ heterotrimers, which increased the number of free Gβγ dimers, promoted the activation of downstream signaling pathways (such as PI3K/AKT), and facilitates the differentiation of SCs. (2) Gnao1 deletion in SCs led to increased synthesis of cAMP, the second messenger in the G protein-coupled receptor signaling pathway, which accelerated SCs differentiation