Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer’s disease

Table 2 Severity scores for cortical and meningeal CAA across individual brain regions

		AD Median (range)	DLB Median (range)	PD Median (range)	PDD Median (range)	p value ^§
Frontal	Cortical	2 (0–3)	0 (0–3)	0 (0)	0 (0–3)	p < 0.001 ^a§
	Meningeal	2 (0–3)	1 (0–3)	0 (0–1)	0 (0–3)	p < 0.001^b§
Temporal	Cortical	0 (0–3)	0 (0–3)	0 (0–1)	0 (0–3)	p < 0.05^c§
	Meningeal	2 (0–3)	0 (0–3)	0 (0–3)	0 (0–3)	p < 0.001 ^d§
Parietal	Cortical	1 (0–3)	0 (0–3)	0 (0–1)	0 (0–3)	p < 0.01 ^e§
	Meningeal	2 (0–3)	0 (0–3)	0 (0–3)	0 (0–3)	p < 0.001 ^f§
Occipital	Cortical	2 (0–3)	0 (0–3)	0 (0–2)	1 (0–3)	p < 0.001 ^gh§
	Meningeal	3 (0–3)	1 (0–3)	0 (0–3)	2 (0–3)	p < 0.001 ^ij§

AD cases had significantly increased man CAA scores compared to DLB, PDD, and PD in all regions assessed. With respect to differences between the LBD groups, meningeal and cortical CAA was significantly different in PDD compared to PD in the occipital cortex (p < 0.05)
AD Alzheimer’s disease, DLB dementia with Lewy bodies, PDD Parkinson’s disease dementia, PD Parkinson’s disease
^aAD > DLB, PD, and PDD all at least p < 0.05
^bAD > DLB, PD, and PDD all p < 0.001
^cAD > DLB p < 0.05
^dAD > DLB, PD, all at least p < 0.001
^eAD > DLB, PD, and PDD p < 0.05
^fAD > DLB, PD, and PDD p < 0.05
^gAD > DLB, PD, all at least p < 0.001
^hPDD > PD p < 0.05
ⁱAD > DLB, PD, all at least p < 0.001
^jPDD > PD p < 0.05
^§Fisher’s exact test

ISSN: 2051-5960