Fig. 7

Cortical synaptophysin and SV2A density differentially correlate with p-tau load. Correlation between p-tau load and (A) synaptophysin and (B) SV2A density are shown per group in regions affected at Braak 4, 5 and 6. Heat-maps are color-coded for correlation coefficient (r), towards blue represents a negative correlations and towards red a positive correlations. For each correlation, the correlation coefficient is reported, together with its p-value. For the correlations highlighted with a square we are also reporting the scatterplots, color-coded for brain area (every data point represents one averaged measurement per layer III and V-VI). Linear mixed model p-values are adjusted for multiple testing (10 correlations per synaptic marker). *p < 0.05, **p < 0.01, ***p < 0.001 after Bonferroni method. Legend: DLB: Dementia with Lewy bodies; ENTC: entorhinal cortex; FusG: fusiform gyrus; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; PHG: parahippocampal gyrus