Fig. 3

Synaptophysin and SV2A density are reduced in PD, PDD and DLB in a region-specific manner compared to controls. A,B) The first row shows the group differences in synaptophysin and SV2A density across all cases, C,D) the second row shows the same group differences within regions grouped per brain areas affected at Braak 4, 5 and 6, and E, F) the last row shows the same group differences within brain areas. Every data point represents one measurement color-coded by brain area. Linear mixed model p-values are adjusted for multiple pairwise (post-hoc) comparisons between groups and multiple testing comparisons for regions affected at Braak stage 4, 5, and 6 in C) and D), and for 8 regions in E) and F). ^#p < 0.100, *p < 0.05, **p < 0.01, ***p < 0.001 after Bonferroni post-hoc test. ACC: anterior cingulate cortex; AI: anterior insula; CTRL: control; DLB: Dementia with Lewy bodies; ENTC: entorhinal cortex; FusG: fusiform gyrus; GFS: superior frontal gyrus; MTG: middle temporal gyrus; PCC: posterior cingulate cortex; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia; PHG: parahippocampal gyrus.^#p < 0.10, *p < 0.05, **p < 0.01, ***p < 0.001