Fig. 4

Detection of PLAGL1 rearrangements by FISH. a-c FISH images showing positive cases (#2–5-7) and d a negative case (#10) (magnifications × 1000). Representative image of a slide hybridized with a PLAGL1 Break-Apart FISH probe. In positive cases, the images show nuclei harboring a split (red and green signals, yellow arrowheads) and a fused signal or an isolated 3’PLAGL1 signal and a fused signal (grey arrowheads). For the negative case, the images show nuclei harboring two intact fused signals FISH, fluorescence in situ hybridization