Outcome: Cognitive abilities measured by the clinical dementia rating sum of boxes | ||||||||
---|---|---|---|---|---|---|---|---|
Total effect | Direct effect | Indirect effect | Proportion mediated | |||||
Estimate (95% CI) | p | Estimate (95% CI) | p | Estimate (95% CI) | P | Estimate (95% CI) | p | |
Neurodegenerative mediators | ||||||||
Neurofibrillary tangles (n = 648) | 2.21(1.20; 3.29) | < 0.001 | 1.33(0.42; 2.38) | 0.002 | 0.88(0.45; 1.38) | < 0.001 | 0.40(0.21; 0.70) | < 0.001 |
Neuritic plaques (n = 648) | 2.21(1.10; 3.24) | < 0.001 | 0.85( − 0.26; 1.94) | 0.13 | 1.36(0.86; 1.96) | < 0.001 | 0.62(0.35; 1.22) | < 0.001 |
TDP-43 (n = 310) | 1.35( − 0.04; 2.82) | 0.06 | 1.25( − 0.13; 2.63) | 0.07 | 0.10( − 0.16; 0.52) | 0.50 | 0.07( − 0.35; 0.54) | 0.52 |
Lewy bodies disease (n = 617) | 2.04(0.97; 3.11) | < 0.001 | 2.03(1.00; 3.08) | < 0.001 | 0.01( − 0.12; 0.17) | 0.92 | 0.003( − 0.07; 0.08) | 0.92 |
Cerebrovascular mediators | ||||||||
Lacunar infarcts (n = 648) | 2.21(1.18; 3.31) | < 0.001 | 2.12(1.11; 3.23) | < 0.001 | 0.09( − 0.05; 0.26) | 0.21 | 0.04( − 0.03; 0.13) | 0.21 |
Hyaline arteriosclerosis (n = 648) | 2.21(1.13; 3.24) | < 0.001 | 2.28(1.23; 3.33) | < 0.001 | − 0.07( − 0.22; 0.05) | 0.25 | − 0.03( − 0.12; 0.02) | 0.25 |
Cerebral Amyloid Angiopathy (n = 648) | 2.21(1.13; 3.29) | < 0.001 | 2.08(0.93; 3.22) | < 0.001 | 0.12( − 0.07; 0.35) | 0.20 | 0.06( − 0.03; 0.20) | 0.20 |