Fig. 5
From: MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
MYC/SMARCA4 tumors show similarities to Group 3/4 MB in DNA methylation analysis. (A) UMAP clustering according to DNA methylation of mouse tumors (Mouse Methylation BeadChip) and human MB (Capper et al. 2018 [9], Sharma et al. 2019 [59], and in-house analyzed samples, n = 228) using 491 orthologous CpG sites out of the 15,000 most differentially methylated CpG sites within the human dataset. Mouse MYC/SMARCA4 tumors (n = 3) show most similarity to MB, Group 3/4. (B) Heatmap clustering according to DNA methylation of the same samples and CpG sites similarly shows proximity of the MYC/SMARCA4 tumors to MB, Group 3/4 (black arrow). (C) Distance Plot using the mean methylation values summarized for every subgroup shows lowest distance of MYC/SMARCA4 tumors to MB, Group 3. MB, G3 = MB, Group 3; MB, G4 = MB, Group 4; MB, SHH CHL AD = Medulloblastoma SHH-activated (children and adults); MB, SHH INF = Medulloblastoma SHH-activated (infants)