Fig. 3
From: MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
Differential gene expression of MYC/SMARCA4 tumors compared to an established mouse SHH MB mouse model. (A) Volcano plot depicting differential gene expression between our MYC/SMARCA4 tumor model (n = 4) and the Math1-cre::Smofl/wt SHH MB mouse model (n = 3) as assessed by RNA sequencing analysis. Only genes orthologous in mice and humans were visualized, and differential expression with logFC ≥ 2.5 and p ≤ 0.01 was considered significant (blue/red coloring) after Benjamini-Hochberg correction. A detailed list of differentially expressed genes is included in Additional File 2, Table S2. (B,C) Gene set enrichment analysis was performed based on significantly differentially expressed genes considering all mouse genes with logFC ≥ 1.5 and p ≤ 0.01. (D,E) Deregulated wiki pathways considering differentially expressed genes across all mouse genes with logFC ≥ 1.5 and p ≤ 0.01