Fig. 2
From: Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
ADbe inoculation accelerates amyloidosis in APPswe/PS1dE9 mice in proximity to the injection site. a–d Representative images of 4G8 immunolabelling showing Aβ pathology in the hippocampus (a, b) and alveus (c, d) of APPswe/PS1dE9 mice eight months after human brain inoculation. e, f Quantification of Aβ load (4G8-positive Aβ plaques per 100 µm2) revealed that ADbe inoculation accelerates Aβ deposition in the hippocampus (e, Mann Whitney's test, U = 21.5, p < 0.0001) and alveus (f, Mann Whitney's test, U = 5, p < 0.0001). ****p < 0.0001. nCtrl = 15, nAD1 = 15 (light pink in e, f), nAD2 = 20 mice (dark pink in e, f). Data are shown as mean ± s.e.m. Scale bars = 100 µm