Fig. 5
From: DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
Altered expression of DNA repair genes in mTBI brains compared to controls, expressed as log2 RNA count number. In a, significantly down-regulated DNA repair genes (n = 37) are: MSH4 (p = 0.0001), FANCA (p = 0.0001), POLD1 (p = 0.0002), NBN (p = 0.001), RAD23B (p = 0.0001), APEX1 (p = 0.004), POLB (p = 0.003), MBD4 (p = 0.007), RAD9A (p = 0.005), ERCC2 (p = 0.01), XPA (p = 0.02), ERCC8 (p = 0.02), XAB2 (p = 0.02), CETN2 (p = 0.02), DMC1 (p = 0.004), XRCC6 (p = 0.002), PMS1 (p = 0.03), XRCC3 (p = 0.03), H2AFX (p = 0.004), BMI1 (p = 0.04) PMS2 (p = 0.003), RAD21 (p = 0.02), MSH3 (p = 0.02), MLH3 (p = 0.04), ERCC3 (p = 0.01), RAD23A (p = 0.01), RAD51C (p = 0.0001), NEIL2 (p = 0.02), MDC1 (p = 0.007), RNF168 (p = 0.02), MSH2 (p = 0.0001), XRCC5 (p = 0.003), NTHL1 (p = 0.02), RPA2 (p = 0.002), NEIL1 (p = 0.006), RAD50 (p = 0.04). In b, significantly up-regulated DNA repair genes (n = 9) are: RAD51B (p = 0.03), RAD52 (p = 0.05), RAD18 (p = 0.05), RAD54L (p = 0.05), MSH5 (p = 0.03), BRCA2 (p = 0.01), MAG1 (p = 0.05), TDG (p = 0.04), NEIL3 (p = 0.03)