Table 1 Tau antibodies tested in preclinical efficacy studies
ANTIBODY | EPITOPE | ANIMAL MODEL | IMPROVEMENT | EFFICACY | REFERENCE | ||
|---|---|---|---|---|---|---|---|
Cognitive | Motor | NFTs | Insoluble tau | ||||
PHF1 | pS396/404 | P301L | nd. | nd. | nd. | Reduced | [56] |
P301S | nd. | Improved | Reduced | Reduced | |||
MC1 | aa7–9 and aa 313–322 | P301L | nd. | nd. | nd. | Reduced | |
P301S | nd. | Improved | Reduced | Reduced | |||
MC1 | aa7–9 and aa 313–322 | P301L | nd. | nd. | Reduced | No change | [72] |
DA31 | aa150–190 | No change | No change | ||||
PHF1 | pSer396/404 | Reduced | Reduced | ||||
4E6G7 | 379-408 (pS396/404) | P301L | nd. | nd. | Reduced | No change | [129] |
6B2G12 | |||||||
TOMA | nd. | Tg2576 | Improved | Improved | nd. | Reduced | [54] |
PHF6 | pT231 | rTg4510 | Improved | No change | nd. | No change | [281] |
PHF13 | pS396 | rTg4510 | Improved | No change | nd. | No change | |
PS19 | Improved | nd. | Reduced | No change | |||
HJ9.3 | aa306–320 | P301S | Improved | No change | Reduced | Reduced | [375] |
HJ9.4 | aa7–13 | Moderate change | No change | Reduced | No change | ||
HJ8.5 | aa25–30 | Moderate change | No change | Reduced | Reduced | ||
HJ8.5 | aa25–30 | P301S | nd. | Improved | Reduced | Reduced | [374] |
43D | aa6–18 | 3xTg-AD | Improved | nd. | Reduced | nd. | [73] |
77E9 | aa184–195 | Improved | nd. | Reduced | nd. | ||
AT8 | pS202 + pT205 | 3xTg-AD | nd. | nd. | Reduced | nd. | [342] |
MAb86 | pS422 | TauPS2APP | nd. | nd. | Reduced | nd. | [61] |
pS404 mAb IgG2 | pS404 | K3 and pR5 | nd. | nd. | Reduced | Reduced | [151] |
pS409-tau | pS409 | P301L | nd. | nd. | Reduced | Reduced | [182] |
Armanezumab | aa2–18 | THY-Tau22 | nd. | nd. | Reduced | nd. | [4] |
PHF1 | pS396/404 | P301L | nd. | Improved | Reduced | No change | [36] |
Ta9 | pS396 | tau609 | Improved | nd. | Reduced | Reduced | [328] |
tau784 | |||||||
Ta4 | pSer396 | tau609 | Improved | No change | Reduced | Reduced | |
tau784 | |||||||
Ta1505 | pSer413 | tau609 | Improved | nd. | Reduced | Reduced | |
DC8E8 | aa268-273, aa299-304, aa330-335, aa362-367 | R3/m4 | nd. | nd. | Reduced | Reduced | [168] |