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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

Fig. 7

α-synuclein levels in CSF of dogs and rats following PBT434 treatment. α-synuclein was collected and quantified from CSF of dogs and rats following PBT434 treatment. a α-synuclein levels of CSF collected from dogs following 28 days exposure to PBT434 at various doses. α-synuclein levels detected by enhanced Western blot decline in the 10 mg/kg, did not reach significance (one-way ANOVA, Tukey post hoc). b Cannula were implanted into the lateral ventricles of wild type rats and CSF was sampled before and after gavage with 30 mg/kg/day PBT434. Western blot for the presence of showed a significant decrease in α-synuclein at 4 h but not at 1 h (* P < 0.05, one-way ANOVA, Tukey post hoc)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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