Fig. 2
Olig001-GFP in NHPs a Representative image of GFP expression in the striatum and corpus callosum of rhesus macaques 4-weeks following injection of Olig001-GFP. Robust GFP expression is seen in the white matter bundles in the striatum and corpus callosum (n = 3) (CC corpus callosum, Cd caudate, Pu putamen, Scale bar 1 mm). b Stereological cell counts revealed an estimated 477,448.33 ± 157,773.29 GFP+ cells, c which had a transduction volume of 52.89mm3 ± 19.17 mm3. d,e Double labeling experiments show that 90–94% of GFP+ cells (green) co-localized with Olig2 (red) (top panel), and only 0.23–1.42% of GFP+ cells co-localized with NeuN (red, middle panel), and only 0.06–0.12% co-localized with GFAP (red, bottom panel). Scale bar 50 μm