From: High plasticity of axonal pathology in Alzheimer’s disease mouse models
dE9xGFP-M | |||||||||
Type of axon | Lifetime (days) | Disappearance of AxDs at the end of the imaging period | Disappearance of the parent axon | Reformation of AxDs | Maximum AxD volume (μm3) | Maximum AxD size ratio | Axonal sprouting | ||
Dys 1 | TB | >168 | No | No | No | 2049 | 22.98 | Yes | |
Dys 2 | EPB | >75 | Yes | Yes | No | 414 | 19.40 | No | |
Dys 3 | EPB | 3a: >10 3b: 62 3c: >6 | No | No | Yes | 3a: 3081 3b: 646 3c: 697 | 3a: 39 3b: 8.18 3c: 8.82 | Yes | |
Dys 4 | TB | 4a: >10 4b: 116 | Yes | No | Yes | 4a: 952 4b: 789 | 4a: 21.3 4b: 17.64 | Yes | |
Dys 5 | EPB | >155 | Yes | Yes | No | 76 | 3.57 | No | |
Dys 6 | EPB | 120 | Yes | Yes | No | 310 | 10.33 | No | |
Dys 7 | EPB | >110 | No | No | No | 150 | 4.83 | No | |
Dys 8 | EPB | >168 | No | No | No | 176 | 5.33 | No | |
Dys 9 | EPB | >168 | No | No | No | 165 | 12.58 | No | |
Dys 10 | EPB | >49 | No | No | No | 458 | 6.83 | No | |
APP-PS1xGFP-M | |||||||||
Type of axon | Lifetime (days) | Disappearance of AxDs at the end of the imaging period | Disappearance of the parent axon | Reformation of AxDs | Maximum AxD volume (μm3) | Maximum AxD size ratio | Axonal sprouting | Regrowth | |
Dys 1 | EPB | 110 | Yes | No | No | 778 | 20.2 | Yes | No |
Dys 2 | EPB | 2a: 47 2b: >88 | No | No | Yes | 2a: 565 2b: 669 | 2a: 9.81 2b: 35.20 | Yes | No |
Dys 3 | TB | >63 | Yes | Yes | No | 514 | 24.49 | Yes | No |
Dys 4 | EPB | 160 | Yes | Yes | No | 2814 | 20.14 | Yes | No |
Dys 5 | TB | >138 | No | No | No | 565 | 14.77 | Yes | No |
Dys 6 | EPB | 124 | Yes | Yes | No | 755 | 16.01 | No | No |
Dys 7 | TB | 95 | Yes | Yes | No | 565 | 4.03 | Yes | No |
Dys 8 | TB | 101 | Yes | Yes | No | 1496 | 27.46 | Yes | No |
Dys 9 | TB | >47 | Yes | No | No | 512 | 21.30 | No | Yes |
Dys 10 | EPB | 59 | Yes | Yes | No | 221 | 8.10 | No | No |
Dys 11 | EPB | 51 | Yes | No | No | 64 | 5.00 | No | No |
Dys 12 | EPB | 72 | Yes | Yes | No | 259 | 9.45 | No | No |
Dys 13 | TB | >131 | No | No | No | 274 | 18.84 | No | Yes |
Dys 14 | EPB | 14a: 29 14b: >40 | No | No | Yes | 14a: 32 14b: 65 | 14a: 2.45 14b: 7.20 | No | No |
Dys 15 | EPB | 15a: >23 15b: 117 | Yes | Yes | Yes | 15a: 116 15b: 203 | 15a: 14.43 15b: 21.05 | No | No |
Dys 16 | TB | 37 | Yes | Yes | No | 48 | 4.80 | No | No |