Fig. 4
From: The identification of human pituitary adenoma-initiating cells
CD15+ pituitary adenoma-initiating cells maintain their tumor initiation potential in human-mouse xenografts. Representative H/E stain of pituitary adenoma xenografts generated from a limiting dilution of CD15high and CD15low adenomas demonstrate (a) tumors with a glandular morphology from CD15high adenomas at a dilution of 1×105 cells (n = 2, ×200) compared to (b) no apparent tumor formation in CD15low xenografts at all dilutions (n = 2, ×200). Whole-mount H/E stain of xenografts show (c) CD15+ adenoma cells to result in significant tumor growth (n = 1, ×4), whereas (d) CD15- adenoma cells are unable to initiate tumor formation (n = 2, ×4). e Low (×50) and (f) high power (×200) images of CD15+ PAIC-generated xenografts