Table 1 Patient demographics and summary of neuropathological analyses
From: Neuropathology of supercentenarians - four autopsy case studies
Case 1 (111 yo) | Case 2 (111 yo) | Case 3 (114 yo) | Case 4 (110 yo) | |
|---|---|---|---|---|
Sex | Female | Female | Female | Female |
Past medical history | HT-, DM- | HT-, DM- | HT-, DM- | HT+, DM- |
Clinical condition before death | Clear communication, wheel chair | No dementia | Clear communication, wheel chair | Almost clear communication, wheel chair |
Barthel index CDR MMSE | 10 0.5 NA due to refusal Age 106 | 60 NA 15 Age 106 | 90 0 22 Age 108 MMSE was 18 at age 113 and 114 | 20 NA NA Age 109 |
Cause of death | Heart failure | Renal failure | Senility | Sepsis |
APOE | 2/3 | 2/3 | 3/3 | 3/3 |
Brain weight (fresh) | 460 (left hemisphere) | 925 | 1,015 | 1,115 |
Atrophy | F, T | F, T | F, T | T |
A-beta, Thal phase | 3 (A2) | 3 (A2) | 1 (A1) | 2 (A1) |
NFT stage (AT8) (Braak) | III (B2) | IV (B2) | III (B2) | IV (B2) |
Neuritic plaques (CERAD) | Moderate (C2) | Moderate (C2) | Sparse (C1) | Moderate (C2) |
CAA | None | None | None | Mild |
AD pathological changes (NIA-Reagan) | Intermediate | Intermediate | Unclassified | Intermediate |
AD pathological changes (NIA-AA) | Intermediate | Intermediate | Low PART possible | Intermediate |
ARTAG | Subpial, subependymal, gray matter, white matter, perivascular | Subpial, gray matter, white matter | Subpial, gray matter, white matter | Subpial, subependymal, gray matter, perivascular |
Arteriolosclerosis | Mild to moderate | Mild to moderate | Mild to moderate | Mild to moderate |
White matter rarefaction | Moderate | Mild | Mild | Moderate |
État criblé (basal ganglia and thalamus) | Moderate | Severe | Severe | Moderate |
Vascular brain injury | Multiple cortical infarcts | None | None | None |
Alpha-synuclein pathology | None | None | None | None |
TDP-43 pathology | Present, subiculum, PHG | Present, subiculum, PHG | Uncus, sparse | Uncus, sparse |
Hippocampal sclerosis | None | None | None | None |
Hirano bodies/GVD (Hippocampus) | Present/present | Present/present | Present/present | Present/present |