Table 1 Changes in IPA canonical pathways in brainstem microglia
IPA canonical pathway | αSYNtg/tg G3Terc-/-vs. controls (p value) | Predicted activity pattern (z score) | αSYNtg/tg vs controls (p value) | Predicted activity pattern (z score) |
|---|---|---|---|---|
Granulocyte Adhesion and Diapedesis | 5,75E-08 | NA | 2,34E-09 | NA |
Atherosclerosis Signaling | 7,76E-07 | NA | 4,27E-07 | NA |
LXR/RXR Activation | 8,51E-08 | Inhibition-0,277 | 9,55E-09 | Activation 2,5 |
cAMP-mediated signaling | ns | NA | 7,59E-06 | Inhibition-0,688 |
Acute Phase Response Signaling | ns | NA | 0,000104713 | Inhibition-0,535 |
Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 3,89E-05 | Inhibition-0,378 | ns | NA |
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | 1,02E-05 | Activation 2,496 | ns | NA |
IL-10 Signaling | 4,57E-05 | NA | ns | NA |
G-Protein Coupled Receptor Signaling | ns | NA | 8,51E-06 | NA |