Region | P8-15 (n) Neonatal | P28-35 (n) Pre-symptomatic | P65-75 (n) Onset | P120 (n) Mid-disease |
---|---|---|---|---|
Soma volume (μm3) | WT: 1339.7 ± 305.4 (7) | WT: 1666.5 ± 142.4 (5) | WT: 1775.5 ± 54.4 (5) | WT: 1666.3 ± 281.3 (8) |
SOD1: 1273.1 ± 242.0 (5) | SOD1: 2446.7 ± 367.1 (5) | SOD1: 24377 ± 96.4 (5) | SOD1: 1432.1 ± 192.9 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Total arbor length (μm) | WT: 2917 ± 522 (7) | WT: 4406 ± 84 (5) | WT: 5527 ± 134 (5) | WT: 4458 ± 389 (8) |
SOD1: 3200 ± 206 (5) | SOD1: 5240 ± 492 (5) | SOD1: 5818 ± 280 (5) | SOD1: 2953 ± 296 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Apical arbor length (μm) | WT: 1734 ± 336 (7) | WT: 2854 ± 191 (5) | WT: 3534 ± 315 (5) | WT: 2512 ± 121 (8) |
SOD1: 2173 ± 256 (5) | SOD1: 2169 ± 143 (5) | SOD1: 3828 ± 232 (5) | SOD1: 1838 ± 224 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Basal arbor length (μm) | WT: 1183 ± 196 (7) | WT: 1551 ± 136 (5) | WT: 1912 ± 254 (5) | WT: 1821 ± 323 (8) |
SOD1: 1027 ± 159 (5) | SOD1: 2061 ± 400 (5) | SOD1: 2331 ± 335 (5) | SOD1: 951 ± 90 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Mean basal tree length (μm) | WT: 333 ± 56 (7) | WT: 469 ± 36 (5) | WT: 461 ± 27 (5) | WT: 371 ± 53 (8) |
SOD1: 326 ± 49 (5) | SOD1: 412 ± 43 (5) | SOD1: 413 ± 40 (5) | SOD1: 253 ± 25 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Apical reach (μm) | WT: 564 ± 68 (7) | WT: 1213 ± 70 (5) | WT: 1265 ± 173 (5) | WT: 922 ± 70 (8) |
SOD1: 720 ± 21 (5) | SOD1: 924 ± 61 (5) | SOD1: 1179 ± 197 (5) | SOD1: 803 ± 99 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Basal reach (μm) | WT: 242 ± 35 (7) | WT: 340 ± 36 (5) | WT: 293 ± 19 (5) | WT: 336 ± 65 (8) |
SOD1: 209 ± 18 (5) | SOD1: 319 ± 13 (5) | SOD1: 299 ± 26 (5) | SOD1: 241 ± 24 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Apical ramifications | WT: 9.2 ± 0.8 (7) | WT: 10 ± 0.6 (5) | WT: 14.3 ± 1.8 (5) | WT: 10.5 ± 1 (8) |
SOD1: 9.4 ± 0.6 (5) | SOD1: 12.7 ± 0.8 (5) | SOD1: 14.9 ± 1.4 (5) | SOD1: 8.4 ± 0.9 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Basal ramifications | WT: 4.1 ± 0.3 (7) | WT: 4.2 ± 0.5 (5) | WT: 4.4 ± 0.3 (5) | WT: 4.5 ± 0.5 (8) |
SOD1: 4.2 ± 0.5 (5) | SOD1: 4.1 ± 0.4 (5) | SOD1: 4.5 ± 0.2 (5) | SOD1: 3.4 ± 0.2 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Apical spine density per 100 μm | WT: 28.9 ± 3.1 (7) | WT: 29.4 ± 3.2 (5) | WT: 32.8 ± 2.8 (5) | WT: 25.7 ± 2.1 (8) |
SOD1: 23.1 ± 3.9 (5) | SOD1: 19.4 ± 3.3 (5) | SOD1: 20.9 ± 2.4 (5) | SOD1: 16.9 ± 1.6 (12) | |
Adj. P = 0.57 | Adj. P = 0.09 | Adj. P = 0.03* | Adj. P = 0.02* | |
Basal spine density per 100 μm | WT: 21.4 ± 2.1 (7) | WT: 22.1 ± 2.2 (5) | WT: 27.9 ± 3.3 (5) | WT: 20.6 ± 3.1 (8) |
SOD1: 16.7 ± 2.9 (5) | SOD1: 16.7 ± 3.4 (5) | SOD1: 20.3 ± 0.8 (5) | SOD1: 13.2 ± 1 (12) | |
Adj. P = 0.79 | Adj. P = 0.66 | Adj. P = 0.21 | Adj. P = 0.04* |