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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Fig. 5

Altered dendritic arbors of SOD1 pyramidal neurons within the MPFC commenced from P8-15, compared to WT controls. Images show mosaics of MPFC pyramidal neurons from P8-15, P28-35, P65-75 and P120 WT (a, c, e, g) and SOD1 (b, d, f, h) mice. i is a scatterplot quantifying significantly decreased total dendritic arbor length (μm) of SOD1 pyramidal neurons (grey squared) compared to WT controls (white circles) at P65-75 and P120. j is a scatterplot quantifying significantly increased basal arbor length (μm) of SOD1 pyramidal neurons (grey squared) compared to WT controls (white circles) at P8-16 and a significant decrease compared to WT at P65-75 and P120. k is a scatterplot quantifying significantly decreased apical dendritic reach (μm) of SOD1 pyramidal neurons (grey squared) compared to WT controls (white circles) at P120. All data are mean ± SEM, with two-way ANOVAs followed by Bonferroni post-tests, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001; n = 7, 5, 5 and 8 for WT P8-15, P28-35, P65-75 and P120 respectively; n = 6, 5, 5 and 12 for SOD1 P8-15, P28-35, P65-75 and P120 respectively. Scale bar: 50 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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