Table 3 Proteins differentially expressed between FTLD-TDP-GRNlτ and FTLD-TDPτ
Spot n° | Protein name | Accession No. | Gene name | p-value | Fold change | Theoretical pI/MW | Apparent pI/MW | Mascot score | % sequence coverage |
|---|---|---|---|---|---|---|---|---|---|
308 | Gelsolin | P06396 | GSN | 0.001 | +1.4 | 5.9/85 | 5.9/85 | 77 | 1.4 |
436 | Neurofilament light polypeptide | P07196 | NEFL | 4.57E-04 | - 1.5 | 4.5/61.5 | 4.5/61.5 | 202 | 34.3 |
Metabolism related proteins | |||||||||
780 | Glyceraldehyde-3-phosphate dehydrogenase (2) | P04406 | GAPDH | 0.001 | +1.3 | 8.6/36 | 8.4/36 | 63.5 | 21.2 |
1040 | Ferritin light subunit | P02792 | FTL | 3.67E-06 | +2.2 | 5.4/20 | 5.4/20 | 354.5 | 30.3 |
738 | Fructose 1.6 biphosphate aldolase | P04075 | ALDOA | 0.0037 | +1.2 | 9.2/39.4 | 9.2/39.4 | 81 | 33.5 |
639 | Alpha-enolase | P06733 | ENO1 | 1.57E-04 | +1.9 | 7.7/47.1 | 7.7/47.1 | 178 | 44.5 |
1033 | Phosphatidylethanolamine-binding protein 1 | P30086 | PEBP1 | 0.007 | +1.3 | 7.4/21 | 8.4/21 | 101 | 56.7 |
956 | Peroxiredoxin 6 | P30041 | PRDX6 | 1.94E-05 | +1.9 | 6.3/25 | 7.0/25 | 147 | 52.2 |
523 | Pyruvate Kinase M (2) | P14618 | PKM | 0.019 | +1.2 | 9.0/60 | 8.4/60 | 93.9 | 31.8 |
708 | Phosphoglycerate kinase 1 | P00558 | PGK1 | 0.023 | +1.2 | 9.2/45 | 9.2/45 | 95.2 | 29.5 |
770 | N(G).N(G)-dimethylarginine dimethylaminohydrolase 1 | O94760 | DDAH1 | 4.36E-04 | +1.3 | 5.5/31.1 | 5.8/43 | 121 | 44.6 |
838 | Guanine nucleotide-binding protein 1 | P62873 | GNB1 | 7.02E-05 | - 1.6 | 5.6/37 | 5.6/37 | 117 | 42.9 |
714 | Creatine Kinase B | P12277 | CKB | 0.004 | - 1.2 | 5.2/42.6 | 5.6/42.6 | 206 | 54.9 |
Astrocytic related proteins | |||||||||
618 | Glial fibrillary acidic protein (3) | P14136 | GFAP | 2.43E-06 | +3.2 | 5.3/49.8 | 5.5/49.8 | 287 | 56.4 |
689 | Glutamine synthetase | P15104 | GLUL | 0.003 | - 1.2 | 6.5/42 | 7.2/42 | 69.4 | 16.4 |
Synaptic related proteins | |||||||||
476 | Dihydropyrimidinase-related protein 2 (2) | Q16555 | DPYSL2 | 4.62E-04 | - 1.3 | 5.9/62.3 | 6.6/62.3 | 274 | 50.1 |
448 | Syntaxin-binding protein 1 (2) | P61764 | STXB1 | 3.70E-04 | - 1.3 | 6.5/67.5 | 7.6/60 | 138 | 22.6 |
Other | |||||||||
883 | Annexin 5 | P08758 | ANXA5 | 1.75E-04 | +1.5 | 4.8/35.9 | 4.8/35.9 | 188 | 45.6 |
976 | Ubiquitin carboxyl-terminal hydrolase isoenzyme L1 | P09936 | UCHL1 | 0.003 | - 1.3 | 5.2/25 | 5.2/25 | 85.8 | 47.1 |
430 | Heat shock 70 kDa protein 1A | P0DMV8 | HSPA1A | 0.002 | +1.3 | 5.4/70 | 5.4/60 | 110 | 27.9 |